Prof. Denis Duboule


+41 22 379 67 71
4004 (Sciences III)
4, Bvd d'Yvoy
CH-1205 Geneva


Genes Dev. 2016 May 19. Pubmed

A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus.

Beccari L, Yakushiji-Kaminatsui N, Woltering J M, Necsulea A, Lonfat N, Rodriguez-Carballo E, Mascrez B, Yamamoto S, Kuroiwa A, Duboule D

Curr Top Dev Biol. 2016;116:299-314. doi: 10.1016/bs.ctdb.2015.11.022. Epub 2016 Jan 27. Pubmed, 616 KB

Topological Domains, Metagenes, and the Emergence of Pleiotropic Regulations at Hox Loci.

Darbellay F, Duboule D

Elife. 2016 Aug 1;5. pii: e16087. doi: 10.7554/eLife.16087. Pubmed, 2.31 MB

Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan.

Guerreiro I, Gitto S, Novoa A, Codourey J, Nguyen Huynh T H, Gonzalez F, Milinkovitch M C, Mallo M, Duboule D

Proc Natl Acad Sci U S A. 2015 Oct 26. pii: 201517972. Pubmed

Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states.

Fabre P J, Benke A, Joye E, Nguyen Huynh T H, Manley S, Duboule D

Mech Dev. 2015 Jul 31. pii: S0925-4773(15)30007-1. doi: 10.1016/j.mod.2015.07.006. Pubmed

Tetrapod axial evolution and developmental constraints; empirical underpinning by a mouse model.

Woltering J M, Duboule D

FEBS Lett. 2015 Apr 22. pii: S0014-5793(15)00282-3. doi: 10.1016/j.febslet.2015.04.024. Pubmed

Structure, Function and Evolution of Topologically Associating Domains (TADs) at Hox loci.

Lonfat N, Duboule D

Proc Natl Acad Sci U S A. 2015 Mar 30. pii: 201504783. Pubmed

Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain.

Vieux-Rochas M, Fabre P J, Leleu M, Duboule D, Noordermeer D

Science. 2014 Nov 21;346(6212):1004-6. doi: 10.1126/science.1257493. Pubmed

Convergent evolution of complex regulatory landscapes and pleiotropy at Hox loci.

Lonfat N, Montavon T, Darbellay F, Gitto S, Duboule D

Methods Mol Biol. 2014;1196:89-102. doi: 10.1007/978-1-4939-1242-1_6. Pubmed

The Genetics of Murine Hox Loci: TAMERE, STRING, and PANTHERE to Engineer Chromosome Variants.

Tschopp P, Duboule D

Nature. 2014 Jul 3;511(7507):46-51. doi: 10.1038/nature13289. Epub 2014 Jun 18. Pubmed

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.

Lopez-Rios J, Duchesne A, Speziale D, Andrey G, Peterson K A, Germann P, Unal E, Liu J, Floriot S, Barbey S, Gallard Y, Muller-Gerbl M, Courtney A D, Klopp C, Rodriguez S, Ivanek R, Beisel C, Wicki...