Prof. Denis Duboule

Duboule

+41 22 379 67 71
4004 (Sciences III)
4, Bvd d'Yvoy
CH-1205 Geneva
Switzerland

Publications

FEBS Lett. 2015 Apr 22. pii: S0014-5793(15)00282-3. doi: 10.1016/j.febslet.2015.04.024. Pubmed

Structure, Function and Evolution of Topologically Associating Domains (TADs) at Hox loci.

Lonfat N, Duboule D

School of Life Sciences, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland. School of Life Sciences, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland; Department of Genetics and Evolution, University of Geneva, 1211 Geneva, Switzerland. Electronic address: denis.duboule@epfl.ch.

Proc Natl Acad Sci U S A. 2015 Mar 30. pii: 201504783. Pubmed

Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain.

Vieux-Rochas M, Fabre P J, Leleu M, Duboule D, Noordermeer D

School of Life Sciences, Swiss Federal Institute of Technology - Lausanne (EPFL), 1015 Lausanne, Switzerland; and. School of Life Sciences, Swiss Federal Institute of Technology - Lausanne (EPFL), 1015 Lausanne, Switzerland; and. School of Life Sciences, Swiss Federal Institute of Technology - Lausanne (EPFL), 1015 Lausanne, Switzerland; and. School of Life Sciences, Swiss Federal Institute of Technology - Lausanne (EPFL), 1015 Lausanne, Switzerland; and Department of Genetics and Evolution, University of Geneva, 1205 Geneva, Switzerland denis.duboule@epfl.ch daan.noordermeer@cgm.cnrs-gif.fr. School of Life Sciences, Swiss Federal Institute of Technology - Lausanne (EPFL), 1015 Lausanne, Switzerland; and denis.duboule@epfl.ch daan.noordermeer@cgm.cnrs-gif.fr.

Science. 2014 Nov 21;346(6212):1004-6. doi: 10.1126/science.1257493. Pubmed

Convergent evolution of complex regulatory landscapes and pleiotropy at Hox loci.

Lonfat N, Montavon T, Darbellay F, Gitto S, Duboule D

School of Life Sciences, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland. School of Life Sciences, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland. School of Life Sciences, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland. Department of Genetics and Evolution, University of Geneva, 1211 Geneva, Switzerland. School of Life Sciences, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland. Department of Genetics and Evolution, University of Geneva, 1211 Geneva, Switzerland. denis.duboule@epfl.ch.

Methods Mol Biol. 2014;1196:89-102. doi: 10.1007/978-1-4939-1242-1_6. Pubmed

The Genetics of Murine Hox Loci: TAMERE, STRING, and PANTHERE to Engineer Chromosome Variants.

Tschopp P, Duboule D

Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA.

Nature. 2014 Jul 3;511(7507):46-51. doi: 10.1038/nature13289. Epub 2014 Jun 18. Pubmed

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.

Lopez-Rios J, Duchesne A, Speziale D, Andrey G, Peterson K A, Germann P, Unal E, Liu J, Floriot S, Barbey S, Gallard Y, Muller-Gerbl M, Courtney A D, Klopp C, Rodriguez S, Ivanek R, Beisel C, Wicki...

1] Developmental Genetics, Department Biomedicine, University of Basel, CH-4058 Basel, Switzerland [2]. 1] Developmental Genetics, Department Biomedicine, University of Basel, CH-4058 Basel, Switzerland [2] Institut National de la Recherche Agronomique, Genetique Animale et Biologie Integrative, F-78350 Jouy-en-Josas, France [3]. Developmental Genetics, Department Biomedicine, University of Basel, CH-4058 Basel, Switzerland. School of Life Sciences, Federal Institute of Technology Lausanne, CH-1015 Lausanne, Switzerland. Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA. Department for Biosystems Science and Engineering, Federal Institute of Technology Zurich and Swiss Institute of Bioinformatics, CH-4058 Basel, Switzerland. 1] Developmental Genetics, Department Biomedicine, University of Basel, CH-4058 Basel, Switzerland [2] Department for Biosystems Science and Engineering, Federal Institute of Technology Zurich and Swiss Institute of Bioinformatics, CH-4058 Basel, Switzerland. Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA. Institut National de la Recherche Agronomique, Genetique Animale et Biologie Integrative, F-78350 Jouy-en-Josas, France. Institut National de la Recherche Agronomique, Domaine Experimental du Pin au Haras, F-61310 Exmes, France. Institut National de la Recherche Agronomique, Domaine Experimental du Pin au Haras, F-61310 Exmes, France. Institute of Anatomy, Department Biomedicine, University of Basel, CH-4056 Basel, Switzerland. Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia. Institut National de la Recherche Agronomique, Biometrie et Intelligence Artificielle, F-31326 Castanet-Tolosan, France. 1] Institut National de la Recherche Agronomique, Genetique Animale et Biologie Integrative, F-78350 Jouy-en-Josas, France [2] Institut National de la Recherche Agronomique, Laboratoire d'Ingenierie des Systemes Biologiques et des Procedes, F-31077 Toulouse, France. 1] Developmental Genetics, Department Biomedicine, University of Basel, CH-4058 Basel, Switzerland [2] Swiss Institute of Bioinformatics, CH-4058 Basel, Switzerland. Department for Biosystems Science and Engineering, Federal Institute of Technology Zurich and Swiss Institute of Bioinformatics, CH-4058 Basel, Switzerland. Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia. Department for Biosystems Science and Engineering, Federal Institute of Technology Zurich and Swiss Institute of Bioinformatics, CH-4058 Basel, Switzerland. Institut Pasteur, Genetique Moleculaire de la Morphogenese and Centre National de la Recherche Scientifique URA-2578, F-75015 Paris, France. Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA. 1] School of Life Sciences, Federal Institute of Technology Lausanne, CH-1015 Lausanne, Switzerland [2] Department of Genetics and Evolution, University of Geneva, CH-1211 Geneva, Switzerland. Developmental Genetics, Department Biomedicine, University of Basel, CH-4058 Basel, Switzerland.

Elife. 2014 Apr 29;3:e02557. doi: 10.7554/eLife.02557. Pubmed

Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci.

Noordermeer D, Leleu M, Schorderet P, Joye E, Chabaud F, Duboule D

School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland. School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland. School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland Department of Molecular Biology, Harvard University, Boston, United States. School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland. Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland. School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland denis.duboule@epfl.ch.

Dev Cell. 2014 Apr 28;29(2):171-187. doi: 10.1016/j.devcel.2014.03.008. Epub 2014 Apr 17. Pubmed

Evolving Hox Activity Profiles Govern Diversity in Locomotor Systems.

Jung H, Mazzoni E O, Soshnikova N, Hanley O, Venkatesh B, Duboule D, Dasen J S

Howard Hughes Medical Institute, NYU Neuroscience Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA. Department of Biology, New York University, New York, NY 10003, USA. Department of Genetics and Evolution, University of Geneva, Sciences III, Quai Ernest-Ansermet 30, 1211 Geneva 4, Switzerland; Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany. Howard Hughes Medical Institute, NYU Neuroscience Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA. Comparative Genomics Laboratory, Institute of Molecular and Cell Biology, A( *)STAR, Biopolis, Singapore 138673, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore. Department of Genetics and Evolution, University of Geneva, Sciences III, Quai Ernest-Ansermet 30, 1211 Geneva 4, Switzerland; School of Life Sciences, Ecole Polytechnique Federale, 1015 Lausanne, Switzerland. Howard Hughes Medical Institute, NYU Neuroscience Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA. Electronic address: jeremy.dasen@nyumc.org.

Cell. 2014 Feb 13;156(4):856-856.e1. doi: 10.1016/j.cell.2014.01.060. Pubmed

SnapShot: Hox Gene Regulation.

Andrey G, Duboule D

School of Life Sciences, Ecole Polytechnique Federale, Lausanne 1015, Switzerland. School of Life Sciences, Ecole Polytechnique Federale, Lausanne 1015, Switzerland; Department of Genetics and Evolution, University of Geneva, Geneva 1211, Switzerland.

Elife. 2014 Aug 14;3:e03058. doi: 10.7554/eLife.03058. Pubmed

Considerations when investigating lncRNA function in vivo.

Bassett A R, Akhtar A, Barlow D P, Bird A P, Brockdorff N, Duboule D, Ephrussi A, Ferguson-Smith A C, Gingeras T R, Haerty W, Higgs D R, Miska E A, Ponting C P

Andrew R Bassett is in the MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom. andrew.bassett@path.ox.ac.uk. Asifa Akhtar is in the Department of Chromatin Regulation, Max-Planck-Institut fur Immunbiologie und Epigenetik, Freiburg im Breisgau, Germany. Denise P Barlow is in the CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. Adrian P Bird is in the Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom. Neil Brockdorff is in the Department of Biochemistry, University of Oxford, Oxford, United Kingdom. Denis Duboule is in the School of Life Sciences, Ecole Polytechnique Federale Lausanne, Lausanne, Switzerland; Department of Genetics and Evolution, Universite de Geneve, Geneva, Switzerland. Anne Ephrussi is in the Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. Anne C Ferguson-Smith is in the Department of Genetics, University of Cambridge, Cambridge, United Kingdom. Thomas R Gingeras is in the Functional Genomics Group, Cold Spring Harbor Laboratory, Cold Spring Harbor, United States. Wilfried Haerty is in the MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom. Douglas R Higgs is in the MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom. Eric A Miska is in the Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom; Department of Genetics, University of Cambridge, Cambridge, United Kingdom. Chris P Ponting is in the MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom; Wellcome Trust Sanger Institute, Cambridge, United Kingdom chris.ponting@dpag.ox.ac.uk.

PLoS Biol. 2014 Jan;12(1):e1001773. doi: 10.1371/journal.pbio.1001773. Epub 2014 Jan 21. Pubmed, link, 2.28 MB

Conservation and divergence of regulatory strategies at hox Loci and the origin of tetrapod digits.

Woltering J M, Noordermeer D, Leleu M, Duboule D

Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland. School of Life Sciences, Federal Institute of Technology, Lausanne, Switzerland. School of Life Sciences, Federal Institute of Technology, Lausanne, Switzerland. Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland ; School of Life Sciences, Federal Institute of Technology, Lausanne, Switzerland.