Department of

In toto live imaging of Erk signaling dynamics in developing zebrafish hepatocytes.

Regional and tissue-wide regulation of signaling pathways orchestrates cellular proliferation and differentiation during organ development. In this study, we established an imaging platform for longitudinal analysis of liver development in live developing zebrafish. We generated hepatocyte-specific transgenic lines for kinase translocation reporters of extracellular signal-regulated kinase (Erk) and c-Jun N-terminal kinase (Jnk) signaling, and with these we captured signaling dynamics that govern rapid expansion of hepatocytes toward creation of the functioning liver at single-cell resolution. Our findings reveal Erk signaling fluctuations as the liver develops and introduce methodology for investigating cell-type specific signaling dynamics during organ morphogenesis.

Milinkovitch's lab makes the cover of PLOS Biology

The editorial team of PLOS Biology selects one light-sheet microscopy images produced by LANE lab.

Understanding Architecture And Evolutionary Patterns In Haplolepidous Peristomes (Dicranidae, Bryophyta) Using Histology And Micro-Morphology

25.07.2023 14:00, Salle de conférence (Museum of Natural History)

Mathilde Ruche (Michelle Price's group).
hosted by: Michelle Price.