staff

Ilham Bahechar

Research assistant in Vertebrate evolution

  • T: +41 22 379 67 98
  • office 4067a (Sciences III)
  • The contribution of neutral evolution and adaptive processes in driving phenotypic divergence in a model mammalian species, the Andean fox Lycalopex culpaeus Journal of Biogeography. 2018;45:1114–1125

    abstract

    Understanding the mechanisms that drive phenotypic divergence along climatic gradients is a long‐standing goal of biogeography. To fulfil this objective, we tested if neutral and/or adaptive effects drive phenotypic diversification. We quantified the effects of neutral evolution and natural selection on morphological variability of a well‐suited mammalian species, the fox, Lycalopex culpaeus.

    see on external website

  • Transcriptome screen for fast evolving genes by Inter-Specific Selective Hybridization (ISSH). BMC Genomics 2010 ;11():126. 1471-2164-11-126. 10.1186/1471-2164-11-126. PMC2838844.

    abstract

    Fast evolving genes are targets of an increasing panel of biological studies, from cancer research to population genetics and species specific adaptations. Yet, their identification and isolation are still laborious, particularly for non-model organisms. We developed a method, named the Inter-Specific Selective Hybridization (ISSH) method, for generating cDNA libraries enriched in fast evolving genes. It utilizes transcripts of homologous tissues of distinct yet related species. Experimental hybridization conditions are monitored in order to discard transcripts that do not find their homologous counterparts in the two species sets as well as transcripts that display a strong complementarity between the two species. Only heteroduplexes that disanneal at low stringency are used for constructing the resulting cDNA library.

    view more details on Pubmed

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