Heterogeneous combinatorial expression of Hoxd genes in single cells during limb development.
Global analyses of gene expression during development reveal specific transcription patterns associated with the emergence of various cell types, tissues, and organs. These heterogeneous patterns are instrumental to ensure the proper formation of the different parts of our body, as shown by the phenotypic effects generated by functional genetic approaches. However, variations at the cellular level can be observed within each structure or organ. In the developing mammalian limbs, expression of Hox genes from the HoxD cluster is differentially controlled in space and time, in cells that will pattern the digits and the forearms. While the Hoxd genes broadly share a common regulatory landscape and large-scale analyses have suggested a homogenous Hox gene transcriptional program, it has not previously been clear whether Hoxd genes are expressed together at the same levels in the same cells.
The origin of the mammalian brain uncovered
The expression levels of three genes determines the predominant mode of neurogenesis and the development the cerebral neocortex in mammals
to be announced
26.09.2018 11:15, 1S059 (Sciences III)
Karin Schumacher (Heidelberg University).
hosted by: Theresa Fitzpatrick.
Our department hosts 12 research laboratories gathering close to 200 scientists, engineers and technical staff. Research topics cover a large variety of topics, such as developmental genetics and neurogenetics, regeneration, evo-devo, physics of biology, phylogenetics or anthropology.more
Teaching life sciences at the University of Geneva is an important duty for all staff scientists. In addition to the bachelor programme, we also propose specific masters and PhD specialisations through various programmes.more
to be announced
Signal transduction in plants: From molecules to phenotypes, and back
Global analysis of the endogenous DNA repair networks and identification of the Shieldin complex
Department of Genetics and Evolution
4, Boulevard d'Yvoy
T: +41 22 379 67 85