Department of

Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes.

The spatial organization of the mammalian genome relies upon the formation of chromatin domains of various scales. At the level of gene regulation in cis, collections of enhancer sequences define large regulatory landscapes that usually match with the presence of topologically associating domains (TADs). These domains often contain ranges of enhancers displaying similar or related tissue specificity, suggesting that in some cases, such domains may act as coherent regulatory units, with a global on or off state. By using the HoxD gene cluster, which specifies the topology of the developing limbs via highly orchestrated regulation of gene expression, as a paradigm, we investigated how the arrangement of regulatory domains determines their activity and function.

How the dragon got its frill

Michel Milinkovitch's team uncovers the developmental process generating the Chamydosaurus frill.

Reproductive biology and behaviour: Veterinarian and biological perspectives

17.09.2019 09:00, 1S081 (Sciences III)

Many speakers (UNIGE).
hosted by: GenEv.