highlights

publications

Rab-mediated trafficking in the secondary cells of Drosophila male accessory glands and its role in fecundity.

The male seminal fluid contains factors that affect female post-mating behavior and physiology. In Drosophila, most of these factors are secreted by the two epithelial cell types that make up the male accessory gland: the main and secondary cells. Although secondary cells represent only ~4% of the cells of the accessory gland, their contribution to the male seminal fluid is essential for sustaining the female post-mating response. To better understand the function of the secondary cells, we investigated their molecular organization, particularly with respect to the intracellular membrane transport machinery. We determined that large vacuole-like structures found in the secondary cells are trafficking hubs labeled by Rab6, 7, 11 and 19. Furthermore, these organelles require Rab6 for their formation and many are essential in the process of creating the long-term post-mating behavior of females. In order to better serve the intracellular membrane and protein trafficking communities, we have created a searchable, online, open-access imaging resource to display our complete findings regarding Rab localization in the accessory gland. This article is protected by copyright. All rights reserved.

news

Stem cells organize themselves into pseudo-embryos

Scientists have developed murine artificial pseudo- embryos capable of forming the three major axes of the body. An innovative tool to potentially replace mammalian embryos in many experimental conditions.

events

Cell adhesion and polarity signaling in making, maintaining and breaking epithelial barriers

20.11.2018 11:00, A150 (Sciences II)

Carien Niessen (Department of Dermatology and CECAD, University of Cologne. Germany).
hosted by: Sandra Citi.

Research

Our department hosts 12 research laboratories gathering close to 200 scientists, engineers and technical staff. Research topics cover a large variety of topics, such as developmental genetics and neurogenetics, regeneration, evo-devo, physics of biology, phylogenetics or anthropology.

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Education

Teaching life sciences at the University of Geneva is an important duty for all staff scientists. In addition to the bachelor programme, we also propose specific masters and PhD specialisations through various programmes.

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Department of Genetics and Evolution
4, Boulevard d'Yvoy
1205 Geneva
Switzerland

office: 4002A
T: +41 22 379 67 85

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