événements et news

publications

Uncovering the Roles of Clocks and Neural Transmission in the Resilience of Circadian Network.

Studies of circadian locomotor rhythms in gave evidence to the preceding theoretical predictions on circadian rhythms. The molecular oscillator in flies, as in virtually all organisms, operates using transcriptional-translational feedback loops together with intricate post-transcriptional processes. Approximately150 pacemaker neurons, each equipped with a molecular oscillator, form a circuit that functions as the central pacemaker for locomotor rhythms. Input and output pathways to and from the pacemaker circuit are dissected to the level of individual neurons. Pacemaker neurons consist of functionally diverse subclasses, including those designated as the Morning/Master (M)-oscillator essential for driving free-running locomotor rhythms in constant darkness and the Evening (E)-oscillator that drives evening activity. However, accumulating evidence challenges this dual-oscillator model for the circadian circuit organization and propose the view that multiple oscillators are coordinated through network interactions. Here we attempt to provide further evidence to the revised model of the circadian network. We demonstrate that the disruption of molecular clocks or neural output of the M-oscillator during adulthood dampens free-running behavior surprisingly slowly, whereas the disruption of both functions results in an immediate arrhythmia. Therefore, clocks and neural communication of the M-oscillator act additively to sustain rhythmic locomotor output. This phenomenon also suggests that M-oscillator can be a pacemaker or a downstream path that passively receives rhythmic inputs from another pacemaker and convey output signals. Our results support the distributed network model and highlight the remarkable resilience of the circadian pacemaker circuit, which can alter its topology to maintain locomotor rhythms.

news

How the lizard gets its pattern

LANE lab's 3D numerical simulations of the ocellated lizard skin colour patterning are published today in Nature Communications.

événements

Structural studies of TORC1 signaling regulation

21.06.2021 12:15, Virtual seminar (unknown)

Lucas Tafur Petrozzi (Molecular Biology).
organisé par: APDU.

Recherche

Notre département regroupe 12 laboratoires de recherche employant un total de presque 200 scientifiques, ingénieurs et techniciens. Les sujets de recherche de ces laboratoires vont de la génétique du développement à la régénération en passant par l'evo-devo, la biologie physique, phylogénétique, la systématique et l'anthropologie.

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Education

Nos professeurs et enseignants participe directement à l'enseignement des sciences de la vie à l'Université de Genève. Nous proposons aussi des spécialisations aux étudiants en master et aux doctorants à travers divers programmes.

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contact

Département de Génétique et Evolution
Quai Ernest-Ansermet, 30
1205 Genève
Suisse

bureau: 4002A
T: +41 22 379 67 85

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