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publications

Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice.

Rodents perceive pheromones via vomeronasal receptors encoded by highly evolutionarily dynamic Vr and Fpr gene superfamilies. We report here that high numbers of V1r pseudogenes are scattered in mammalian genomes, contrasting with the clustered organization of functional V1r and Fpr genes. We also found that V1r pseudogenes are more likely to be expressed when located in a functional V1r gene cluster than when isolated. To explore the potential regulatory role played by the association of functional vomeronasal receptor genes with their clusters, we dissociated the mouse from its native cluster via transgenesis. Singular and specific transgenic transcription was observed in young vomeronasal neurons but was only transient. Our study of natural and artificial dispersed gene duplications uncovers the existence of transcription-stabilizing elements not coupled to vomeronasal gene units but rather associated with vomeronasal gene clusters and thus explains the evolutionary conserved clustered organization of functional vomeronasal genes.

news

D’où viennent les motifs sur la peau des lézards

Dans la revue Current Biology, l'équipe du professeur M. Milinkovitch quantifie la prévisibilité des modèles échelle par échelle chez plusieurs espèces divergentes de lézards.

événements

BacPROTACs - antibiotics of the future?

13.12.2022 11:00, A150 (Sciences II)

Tim Clausen (IMP Vienna).
organisé par: Robbie Loewith.

Recherche

Notre département regroupe 12 laboratoires de recherche employant un total de presque 200 scientifiques, ingénieurs et techniciens. Les sujets de recherche de ces laboratoires vont de la génétique du développement à la régénération en passant par l'evo-devo, la biologie physique, phylogénétique, la systématique et l'anthropologie.

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Département de Génétique et Evolution
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