A function for all posterior Hoxd genes during digit development?

  • publication
  • 01-03-2012

Delpretti S, Zakany J, Duboule D. Dev. Dyn. 2012 Apr;241(4):792-802. 10.1002/dvdy.23756.

Four posterior Hoxd genes, from Hoxd13 to Hoxd10, are collectively regulated during the development of tetrapod digits. Besides the well-documented role of Hoxd13, the function of the neighboring genes has been difficult to evaluate due to the close genetic linkage and potential regulatory interferences. We used a combination of five small nested deletions in cis, involving from two to four consecutive genes of the Hoxd13 to Hoxd9 loci, in mice, to evaluate their combined functional importance.

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