A new HLA map of Europe: Regional genetic variation and its implication for peopling history, disease-association studies and tissue transplantation.

  • publication
  • 01-01-2013

Sanchez-Mazas A, Buhler S, Nunes JM. Hum. Hered. 2013 ;76(3-4):162-77. 000360855. 10.1159/000360855.

HLA genes are highly polymorphic in human populations as a result of diversifying selection related to their immune function. However, HLA geographic variation worldwide suggests that demographic factors also shaped their evolution. We here analyzed in detail HLA genetic variation in Europe in order to identify signatures of migration history and/or natural selection.

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