Does NGS typing highlight our understanding of HLA population diversity? Some good reasons to say yes and a few to say be careful.

• publication
• 06-11-2018

Sanchez-Mazas A, Nunes JM. Hum. Immunol. 2018 Nov;():. S0198-8859(18)30926-1. 10.1016/j.humimm.2018.10.004.

This paper discusses the advantages provided by next generation sequencing (NGS) compared to traditional typings or limited sequencing strategies for the characterization of HLA population diversity based on four documented examples. We also comment the limitations of this approach by highlighting pitfalls in interpreting NGS data.

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