collaborateurs

Lou Duret

Post-doctorant chez Neuroscience & neurodégénerescence

  • T: +41 22 379 34 91
  • office 3005a (Sciences III)

  • The intertwined relationship between circadian dysfunction and Parkinson's disease. Trends Neurosci 2025 Jan;48(1):62-76. 10.1016/j.tins.2024.10.006. S0166-2236(24)00203-0.

    résumé

    Neurodegenerative disorders represent a leading cause of disability among the elderly population, and Parkinson's disease (PD) is the second most prevalent. Emerging evidence suggests a frequent co-occurrence of circadian disruption and PD. However, the nature of this relationship remains unclear: is circadian disruption a cause, consequence, or a parallel feature of the disease that shares the same root cause? This review seeks to address this question by highlighting and discussing clinical evidence and findings from experiments using vertebrate and invertebrate animal models. While research on causality is still in its early stages, the available data suggest reciprocal interactions between PD progression and circadian disruption.

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  • Circadian clock disruption promotes the degeneration of dopaminergic neurons in male Drosophila. Nat Commun 2023 Sep;14(1):5908. PMC10516932. 10.1038/s41467-023-41540-y. 10.1038/s41467-023-41540-y.

    résumé

    Sleep and circadian rhythm disruptions are frequent comorbidities of Parkinson's disease (PD), a disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra. However, the causal role of circadian clocks in the degenerative process remains uncertain. We demonstrated here that circadian clocks regulate the rhythmicity and magnitude of the vulnerability of DA neurons to oxidative stress in male Drosophila. Circadian pacemaker neurons are presynaptic to a subset of DA neurons and rhythmically modulate their susceptibility to degeneration. The arrhythmic period (per) gene null mutation exacerbates the age-dependent loss of DA neurons and, in combination with brief oxidative stress, causes premature animal death. These findings suggest that circadian clock disruption promotes dopaminergic neurodegeneration.

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