24 Nov 2015
Researchers in the laboratory of Michel Milinkovitch have identified in the corn snake the mutation responsible for amelanism, a form of albinism due to a defect in the production of melanin (the black and brown pigments of the skin). The skin of the wild type corn snake exhibits a light orange background colour covered with a pattern of dark orange dorsal saddles and lateral blotches that are outlined with black. However, some individuals do not correspond to that standard morphology: they lack all signs of melanin in the skin and eyes. The Swiss team decided to search for the DNA mutation that determines that specific coloration. To this end, they bred wild-type corn snakes with amelanistic individuals and they sequenced each offspring born from that cross. “Thanks to that large amount of sequencing data, we identified the malfunctioning gene”, explains Milinkovitch. That gene is called OCA2 and codes for a receptor located in the membranes of intracellular compartments, called melanosomes, that contain melanin. This receptor controls the proper level of acidity allowing for the synthesis of melanin.