Analysis of the dynamics of limb transcriptomes during mouse development.

  • publication
  • 02-08-2011

Gyurján I, Sonderegger B, Naef F, Duboule D. BMC Dev. Biol. 2011 ;11():47. 1471-213X-11-47. 10.1186/1471-213X-11-47. PMC3160909.

The development of vertebrate limbs has been a traditional system to study fundamental processes at work during ontogenesis, such as the establishment of spatial cellular coordinates, the effect of diffusible morphogenetic molecules or the translation between gene activity and morphogenesis. In addition, limbs are amongst the first targets of malformations in human and they display a huge realm of evolutionary variations within tetrapods, which make them a paradigm to study the regulatory genome.

see on Pubmed