Worldwide distribution of NAT2 diversity: implications for NAT2 evolutionary history.

  • publication
  • 29-02-2008

Sabbagh A, Langaney A, Darlu P, Gérard N, Krishnamoorthy R, Poloni ES. BMC Genet. 2008 ;9():21. 1471-2156-9-21. 10.1186/1471-2156-9-21. PMC2292740.

The N-acetyltransferase 2 (NAT2) gene plays a crucial role in the metabolism of many drugs and xenobiotics. As it represents a likely target of population-specific selection pressures, we fully sequenced the NAT2 coding region in 97 Mandenka individuals from Senegal, and compared these sequences to extant data on other African populations. The Mandenka data were further included in a worldwide dataset composed of 41 published population samples (6,727 individuals) from four continental regions that were adequately genotyped for all common NAT2 variants so as to provide further insights into the worldwide haplotype diversity and population structure at NAT2.

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