Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults.

  • publication
  • 20-05-2017

Yang H, Basquin D, Pauli D, Oliver B. BMC Genomics 2017 May;18(1):384. 10.1186/s12864-017-3755-x. 10.1186/s12864-017-3755-x.

Transcriptional elongation is a generic function, but is also regulated to allow rapid transcription responses. Following relatively long initiation and promoter clearance, RNA polymerase II can pause and then rapidly elongate following recruitment of positive elongation factors. Multiple elongation complexes exist, but the role of specific components in adult Drosophila is underexplored.

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