Large scale genomic reorganization of topological domains at the HoxD locus.

  • publication
  • 09-08-2017

Fabre PJ, Leleu M, Mormann BH, Lopez-Delisle L, Noordermeer D, Beccari L, Duboule D. Genome Biol. 2017 Aug;18(1):149. 10.1186/s13059-017-1278-z. 10.1186/s13059-017-1278-z. PMC5547506.

The transcriptional activation of HoxD genes during mammalian limb development involves dynamic interactions with two topologically associating domains (TADs) flanking the HoxD cluster. In particular, the activation of the most posterior HoxD genes in developing digits is controlled by regulatory elements located in the centromeric TAD (C-DOM) through long-range contacts.

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