Evaluating the impact of scoring parameters on the structure of intra-specific genetic variation using RawGeno, an R package for automating AFLP scoring.

  • publication
  • 28-01-2009

Arrigo N, Tuszynski JW, Ehrich D, Gerdes T, Alvarez N. BMC Bioinformatics 2009 Jan;10():33. 1471-2105-10-33. 10.1186/1471-2105-10-33. PMC2656475.

Since the transfer and application of modern sequencing technologies to the analysis of amplified fragment-length polymorphisms (AFLP), evolutionary biologists have included an increasing number of samples and markers in their studies. Although justified in this context, the use of automated scoring procedures may result in technical biases that weaken the power and reliability of further analyses.

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